Cover art for podcast The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

934 EpisodesProduced by Dave AspreyWebsite

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own pe… read more


GUT HEALTH: Enzymes Do the Heavy Lifting – A Top 10 Episode with BiOptimizers

Welcome to Your Upgraded Summer!

This new series revisits the Top 10 Bulletproof Radio episodes of all time. The topics cover essentials like nutrition, energy, hormones, sleep and autophagy, as well as gut, brain, autoimmune and women's health.

You'll get the main points in a shortened version so you can get the good stuff and get on with your summer plans. And if you want to listen to more, tune in to the original episode.

 The BiOptimizers guys take the No. 6 spot with: How to BiOptimize Your Gut & Digestion – #515

In this episode of Bulletproof Radio, we’re revisiting an episode with Wade Lightheart and Matt Gallant, founders of BiOptimizers. They aim to optimize digestion, leading into better health and greater performance. Just like me, they believe holistic health, with a focus on body and brain, makes us higher functioning humans.

Wade is a former three-time Canadian, natural bodybuilding champion. Matt’s a kinesiologist who’s trained pro athletes and has been developing supplements for more than a decade. Together at BiOptimizers, they’ve tackled gut, body and brain health with an emphasis on enzymes, prebiotics and probiotics, magnesium, and blood sugar.

“We all have an enzyme bank account in our bodies and they do about 25,000 different functions in the body,” Matt says. 

“Everything from thinking to blinking, enzymes are involved. They’re the catalyst that kickstarts chemical biochemical reactions in the body. And when we eat food, we need to break that food down. So our body's going to use our enzymatic bank account to break that food down.”

Certain kinds of enzymes help with carbohydrate digestion, protein and fiber breakdown, losing body fat, improving skin conditions, clearing brain fog and speeding up recovery.

“Depending on what you're eating,” Matt says, “your brain is going to recognize what enzymes it needs to produce and then start breaking that down in the mouth and then continuing to excrete enzymes inside your stomach.”

And when you do your own biofeedback (paying attention to how your body respond to different stimuli) you’ll find what works for you, and what enzymes can help make your body work more efficiently.

“I got so into enzymes and their usage because I knew that I really couldn't perform at a high level on that diet [vegetarian] if I didn't have really superior digestion. And then that inadvertently trying to solve that problem as an athlete translated over to all sorts of people who I discovered had digestive-related illnesses and we could actually solve those, and that led to a whole cascade of things and eventually a company and all that sort of stuff. So, you scratch your own head, and you start up with a toaster and end up with a rocket ship.”

Enjoy! And get more resources at Dave.Asprey/podcasts.

Got a comment, idea or question for the podcast? Submit via this form.


BiOptimizers: Go to and use code DAVE10




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