Cover art for podcast The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

985 EpisodesProduced by Dave AspreyWebsite

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own pe… read more


Toss the Candles! Biological Age Is Your New Birthday – Ryan Smith : 883


Nature’s Nootropic:, use code DAVE15 for 15% off

Support Immune & Digestive Health:, use code ASPREY to get 15% off

Eat Good Keto Bread:, use code DAVE to get $10 off the starter bundle. That includes two superfood cubes and a four pack of freedom chips!


You can order TRUAGE at and enter code ASPREY at checkout for $50 off.


 …you’re going to discover how old you really are by taking a dive into the science of epigenetic methylation and biological aging. You’re going to find out about gene function, gene expression and what it has to do with how you age—and why it matters.

Biochemist Ryan Smith co-founded TruDiagnostic, a company focused on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic, a CLIA certified lab and health data company, developed the TRUAGE anti-aging test. 

From a small blood test, TruDiagnostic can tell you your biological age—how old your body acts, based on how it’s functioning (as opposed to your chronological age, which is the number of years you’ve been on Earth). 

Biological age is one of the most impactful pieces of data you can have about yourself. Age is the number one predictor of death, and your biological age matters more than the number of times you’ve been around the sun.  

For example, you could be 42, and if you take great care of yourself, your biological age may be 30… Or, if you take poor care of yourself, your biological age may be 60. 

Either way, TruDiagnostic will tell you how old you really are. And their test goes further than that. After you discover your biological age, TruDiagnostic also gives you a list of strategies to reverse aging based on your unique genetics. In other words, you get personalized anti-aging biohacks—and you can test your age over time to see if you’re getting younger, so you know whether or not your anti-aging hacks are working.

If you can turn back the clock on your biological age, you unlock the door to a longer, better life. 

It feels like the cusp of a big change in longevity research with science and data now more fully supporting this work. TruDiagnostic currently has over 30 approved clinical research studies underway investigating how epigenetic methylation changes impact how long you live and how well you age.

In this episode, you’ll also learn:

  • Why men age worse than women, and what you can do about it
  • The best ways to predict your biological age (hint: grip strength is one of them)
  • How getting COVID changes the speed at which you age
  • Why small amounts of stress are amazing for anti-aging (and the right ways to stress your body and brain so you age in reverse)

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