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The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

937 EpisodesProduced by Dave AspreyWebsite

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own pe… read more


How Hacking Your Gut Bacteria Can Regulate Your Blood Sugar – Colleen Cutcliffe, Ph.D., with Dave Asprey : 767

In this episode of Bulletproof Radio, my guest is Colleen Cutcliffe, Ph.D., CEO and co-founder of Pendulum Therapeutics. We explore exciting new discoveries in the body’s gut microbiome and discuss how Pendulum is disrupting what we know about probiotics.

Pendulum uses biological and computational insights into the microbiome to develop solutions for health and disease conditions. 

“Rather than calling a disease by what the symptoms are, we are actually looking at the microbiome as an underlying infrastructure within our body,” Colleen says. 

Pendulum also identifies and isolates new bacterial strains, then combines those new strains to create unique probiotics. These are backed by clinical research studies. Using this discovery platform, Pendulum created the world’s first microbiome intervention for people with Type 2 Diabetes. 

“Managing your blood sugar is at the core of so many health issues, including your immune system,” Colleen says. “You really are more vulnerable and susceptible when you're not managing your blood sugars properly.”

In Pendulum’s clinical testing, they found out some interesting things.

“We have people with type 2 diabetes on multiple drugs,” Colleen says. “We have people with pre-diabetes who are looking to avoid crossing over into taking drugs. And we've had people who are healthy that are really concerned about “how is my body metabolizing sugar and fibers.” And so we offer free A1c testing, actually at baseline, and then three months in so that people can see their results. And I think that really helps people kind of believe the results that they're experiencing.”

Our conversation goes in a lot of directions related to the science of gut healthboth your inner environment and the one around you. We’re learning so much, so fast, that science is seeing all sorts of connections. The gut microbiome is the frontier of how we’ll define better health.

“Where we're heading is understanding that the microbiome is foundational in a lot of things like the immune response, allergies, digestion, metabolism, and that once you start to make sure that you have the right flora and all the right plants in your garden, you're actually going to be tackling a lot of these different things,” Colleen says. “And so, you won't have to have a specific thing for every disease because I think we're going to transform the way we think about disease.”

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