Cover art for podcast The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

985 EpisodesProduced by Dave AspreyWebsite

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own pe… read more


Hacking Longevity Starts with Detoxification – Chris Shade, Ph.D. : 884


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 … Christopher Shade, Ph.D., joins the show to take you through a new six-spoke “longevity wheel.” You’ll find out what you can do to live longer by managing toxins and hormones that influences aging.

With expertise in environmental sciences, chemistry and biology, he founded the Colorado-based company Quicksilver Scientific. It’s a group of “chemists, biohackers and age rebels.”

He specializes in the biological, environmental, and analytical chemistry of mercury in all its forms. He presents and teaches in the U.S. and nationally about mercury, environmental toxicities, neuroinflammation, immune dysregulation, and the human detoxification system.

He's designed detoxification protocols, unique supplement delivery systems, and a patented mercury speciation test. As CEO, he continually drives development and innovation. Right now, the focus is longevity with a foundation in detoxification.

Everyone has a meaningful amount of metals, plastics, molds or other toxins in their body and is pretty much operating with low-grade toxicity. And even though everyone has the same basic detoxification system, people react to and process toxins very differently. 

There’s a general universe of toxins: You have exogenous toxins from outside the body (metals, chemicals, mycotoxins or food-borne toxins). Then you have endotoxins, which are made on board usually by gut bacteria and lipopolysaccharide.

That’s why cellular level detoxification matters so much. Bile flow, and knowing what blocks it and what opens it, plays a huge role in your body’s detoxification process.

If you learn to think like a computer or especially a network engineer, there's a whole bunch of interrelated systems. If one of them is broken, it'll have an effect on the other. But when you look at detox pathways, you look at aging, it's a very similar mindset, way more so than you would think.

Hormones, too, get in on the aging action. DHEA and pregnenolone are the mother hormones. All the other hormones are made out of those two things. “Hormones are necessary for all the detox reactions,” Chris says. “Having the right levels of all the hormones just powers everything up.”

The six-spoke “Longevity Wheel” framework that Chris developed biohacks conventional aging assumptions. This wheel is a collection of biochemical pathways, mechanisms, and molecules that impact aging. Each spoke builds on another and all work together. 

  • Nrf2 and AMPK
  • NAD
  • Sirtuins
  • Telomeres
  • Senolytics
  • Neuroendocrine

Listen on to find out more about how detox, hormones and the spokes of this new Longevity Wheel can impact how you age.

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