Cover art for podcast The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

The Human Upgrade with Dave Asprey—formerly Bulletproof Radio

937 EpisodesProduced by Dave AspreyWebsite

For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own pe… read more


Hack Your Neurochemistry with Customized Nootropics – Mr. Noots & Matt Gallant : 861


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We’re going deep on all things nootropics. Stacks, timing and what works for your brain.

I didn’t want to be the guy who made nootropics. I wanted it to be the fact that it’s possible, therefore, let’s all do it. I mean, take them and let’s all make them. We need creators who build stuff that’s real. I just want people to see it was real so that we could all build it.

You’re going to learn a lot in this episode, like:

  • The promise of nootropics vs. the reality of nootropics
  • Problems with typical nootropics
  • How brain chemistry and nervous systems are incredibly unique
  • How every high-performance state has a corresponding neurochemistry stack
  • Nine Nootopia base blends that have specific goals and purposes
  • Why Nootopia nootropics are different
  • Tips to get the most out of your nootropics


One of today’s guests has been on the show several times to talk about psychobiotics, magnesium, enzymes and blood sugar.

As co-founder of BiOptimizers, Matt Gallant keeps researching and innovating ways to keep your whole body healthy. He sees important connections within body systems and finds unique ways to maximum human performance. He especially likes the brain and will be talking about new developments in nootropics that can be customized to your own body system.

Matt Gallant: “A lot of nootropics rely on brute force,” Matt says. “They hammer one receptor or one pathway and they just push it to the max which has negative consequences, receptors downregulate, you can have more side effects. As a former addict, I thought, and I was hardwired to believe that more is better. And now I know better and optimal is better. So, it's about really finding the optimal dose for each person. And that's why we're all about customization and personalization.”

He’s joined by Mr. Noots, his partner in custom nootropic development. 

Between ages 5 and 10, he built radio, conducted dangerous chemistry experiments and built a Helium-Neon Laser from scratch. His favorite childhood activities were science, chemistry and physics. He spent his 20’s in the US Air Force, which was the perfect platform to become an endurance athlete and eventual bodybuilder. Life happened and as Mr. Noots moved from sick to superhuman, he dove deep into performance-enhancing nutrition. That, in turn, led him to become a Chief Product Officer for the mind-enhancing compounds and stacks of nootropics at Nootopia.

“This is one of the things where I want everyone listening to just say, "Okay, I admit to myself that it is possible for plant extracts or other compounds to improve cognitive function because it's abundantly obvious,” “says Mr. Noots.

Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.

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