Optimal Health Weekly Podcast

Welcome to the first show of 2023. In this episode of Optimal Health Weekly we discuss the the latest advancements in multiple sclerosis research.

Using a novel strategy, scientists have isolated signalling molecules that control the activation of specific subsets of astrocytes, which are implicated as the primary inflammatory drivers in multiple sclerosis (MS). FIND-seq is a new technique that allows for the isolation and comprehensive gene expression analysis of single cells within a sample based on their expression of a specific gene or set of genes. Using cells from a mouse model of multiple sclerosis, scientists discovered that the proteins NR3C2 and NCOR2 can suppress the activity of disease-promoting astrocytes by inhibiting the movement of the XBP1 protein. Neuroinflammation and neurodegeneration in the brain may be mitigated through the manipulation of these molecules.

Researchers looked at brain tissue from people with MS to back up their findings. A decrease in NR3C2 levels and indicators of decreased NR3C2-NCOR2 signalling was found in astrocytes compared to healthy tissue. Together, these results indicate that disease-promoting astrocyte activities that contribute to CNS pathology are under the control of the equilibrium between XBP1 and NR3C2-NCOR2 signalling. To combat neuroinflammation and neurodegeneration, inhibiting NR3C2 and NCOR2 may be a promising new treatment option for MS and related disorders.

Links mentioned in show:

• https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/symptoms-causes/syc-20350269
• https://www.nationalmssociety.org/What-is-MS
• https://stemcellthailand.org/therapies/multiple-sclerosis-ms/
• https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/multiple_sclerosis/conditions/
• https://www.msaustralia.org.au/what-is-multiple-sclerosis-ms/

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2 - Risks and Benefits of Intermittent Fasting 

3- Confronting Alzheimer's  

4 - Prevent and treat heart disease

5 - Chronic Liver Disease 

6 - Lung Injuries Associated with Vaping

7 - Crohn's and Ulcerative Colitis

8 - Kidney Failure & IgA Nephropathy 

9 - Brain Injuries

10 - Stroke

11 - Spinal Injury

12 - Lyme Disease

13 - Autoimmune Disease

14 - Diabetes

15 - Parkinsons

16 - ALS