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Blood & Cancer

70 EpisodesProduced by MDedge Hematology OncologyWebsite

Interview-style hematology/oncology podcast from MDedge Hematology-Oncology. The show is hosted by Dr. David Henry with Pearls from Dr. Ilana Yurkiewicz for clinical hematology and oncology health care professionals. The information in this podcast is provided for informational and educational purpo… read more

32:35

CAR T-cell therapy: Development to access

 

Howard “Skip” Burris, MD, the chief medical officer at Sarah Cannon Cancer Institute in Nashville, Tenn., joins the podcast as a guest host for a discussion on chimeric antigen receptor (CAR) T-cell therapy with Helen Heslop, MD, of Baylor College of Medicine, Houston. Dr. Heslop, who has been a leader in CAR T-cell therapy research, recently received a Lifetime Achievement Award from the American Society for Blood and Marrow Transplantation.

 

Contact the show: podcasts@mdedge.com or follow us on Twitter at @MDedgeHemOnc.

 

EP 14 Show Notes:

By Emily Bryer, DO, is a resident in the department of internal medicine, University of Pennsylvania, Philadelphia.

  • Checkpoint inhibition is the main immunotherapy used in oncology; this allows endogenous T cells to react against targeted antigens on tumor cells.
  • CAR T-cell therapy: Autologous product (T cells collected from recipient) are expanded ex vivo, genetically modified with chimeric antigen receptor, and then are reinfused into the patient.
  • While antibody treatment can be used for multiple patients, CAR T-cell therapy is currently patient specific and autologous.
  • Current candidates for CAR-T therapy:
    • Acute lymphoblastic leukemia (ALL) in children and young adults.
    • CD19 diffuse large B-cell lymphoma.
  • There is a 40% response rate plateau at 2 years with CAR-T therapy, with lymphoma response rates lower than those of pediatric ALL.
  • CAR T-cell therapies likely will continue to be done on an inpatient basis because of significant side effects:
    • Cytokine release syndrome and neurotoxicity.
  • Future directions for CAR-T therapy:
    • Continue ongoing studies in mantle cell lymphoma and chronic lymphocytic leukemia.
    • Investigate the potential to replace autologous transplant with CAR T-cell therapy.
    • Maintain and enhance activity of CAR by promoting immune response with multiple antigens, such as CD19 + CD22.
    • Reduce complications associated with CAR-T therapy.
    • Study CAR-T therapy earlier in the disease process.

Image credit: Caron A. Jacobson and Jerome Ritz/Wikimedia Commons/Public Domain

References:

 

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