This audio program discusses a follow-up investigation of patients with major depression over intervals as long as 31 years to determine whether subclinical hypomanic symptoms at baseline were related to the later emergence of bipolar disorder; a 7-year study examining whether children who experience abuse, bullying, or accidents are more likely to develop psychotic symptoms; baseline number of glucocorticoid receptors as a possible biomarker of posttraumatic stress symptoms, tested in military personnel with and without high levels of PTSD symptoms after 6 months of deployment; a further examination of the association between suicide and high altitude that included the influence of gun ownership and rural location; and whether the relationship between paternal age and schizophrenia risk is the result of de novo mutations or later fatherhood for men with a predisposition to schizophrenia. Articles can be viewed online at www.ajp.psychiatryonline.org.
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