American Journal of Psychiatry Audio

Executive Editor Michael Roy speaks with Thorhildur Halldorsdottir, Ph.D., and Elisabeth Binder, M.D., Ph.D., about their research on predicting depression outcomes in youths and how the interaction between FKBP5, a gene involved in regulating the stress system, and early-life exposure to intimate partner violence affects the physiological response to stress early in life, with consequences for emotional and cognitive development.

• How polygenic risk scores may be used to identify risk for and symptoms of depression in young people [3:32]
• The interaction between exposure to stress in early life and emotional and cognitive development [8:05]
• Key points from each study [10:26]
• Applying gene-by-environment research to real-world work [14:27]
• What lies ahead in the study of how genes and the environment interact to influence mental health [16:34]

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